Pathology of Covid-19 Research Models, Domestic and Wildlife Species

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of Coronavirus Disease 2019 (COVID-19), and animal models are imperative to understand the pathogenesis of COVID-19 and to develop therapeutics and vaccines. Here, we discuss New World (Callithrix jacchus) and Old World non-human primate (NHP) (Macaca mulatta and Papio spp.) and rodent models of SARS-CoV-2 infection developed and characterized at Texas Biomedical Research Institute and compare and contrast to pathology described naturally infected domestic and wildlife species.