The first part of this module addresses the importance of foot-and-mouth disease, vesicular stomatitis, swine vesicular disease, vesicular exanthema of swine, and Senecavirus A in the United States. Clinical signs associated with vesicular diseases and specific biosecurity measures are included. The second part of this module takes the veterinarian through an interactive scenario investigating a possible vesicular disease outbreak on a swine farm. Veterinarians learn the process of reporting a possible vesicular disease case and the chain of events that occur in a foreign animal disease investigation.