This presentation explores the complex landscape of chemotherapy in both human and veterinary oncology, shedding light on the differences in treatment goals and drug regimens. While chemotherapy in humans often prioritizes extending life expectancy, veterinary care emphasizes enhancing the quality of life for pets facing cancer diagnoses, acknowledging their inability to verbalize symptoms. The familiar side effects of chemotherapy in humans, such as nausea, vomiting, hair loss, and bone marrow suppression, are distressing and commonly anticipated by pet owners. However, understanding the divergent treatment objectives is crucial, with a focus on sustaining normalcy and quality of life in pets when a cure is unattainable. The presentation delves into common chemotherapeutic agents like Carboplatin, Doxorubicin, L-asparaginase, Mechlorethamine, Mitoxantrone, Vinblastine, Vincristine, Chlorambucil, Cyclophosphamide, Lomustine, and Toceranib, detailing their applications, monitoring parameters, administration protocols, excretion pathways, and potential toxicities. By recognizing the distinctions in treatment approaches and familiarizing themselves with common chemotherapeutics, owners and caregivers can better navigate the challenging journey of cancer treatment for their beloved pets, ultimately improving patient care and outcomes.