As more states pass laws allowing medical and recreational use of marijuana, we are seeing a subsequent increase in the number of toxicities to household pets. While most affected animals can be treated with outpatient or minimal inpatient care, some ingestion cases require more invasive management. This lecture examines the clinical signs, monitoring, and medical management of marijuana toxicosis cases. We will also discuss in depth the case of a domestic ferret that needed mechanical ventilation after ingesting CBD oil.